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Scientist Investigating SARS-CoV-2 Virus Suggests Possible Indications of Simulation Existence





A physicist specializing in the study of mutations in the SARS-CoV-2 virus has put forward intriguing evidence supporting a potential new law of physics known as the “second law of infodynamics.”. This discovery raises fascinating questions about the nature of our reality and the possibility of living in a simulated universe. In addition, he suggests that the study seems to suggest that the theory of evolution is incorrect, as it challenges the notion that mutations are completely random.

There is a great deal of complexity to delve into in this situation. It is important to note that making extraordinary claims necessitates providing extraordinary evidence. However, as Dr. Melvin Vopson elucidates in his research, we currently lack such evidence. Actually, we are far from reaching that point. Nevertheless, the concepts and findings presented are captivating and thought-provoking, even if additional research or examination may later disprove them.

In his most recent study, Vopson examined mutations in the SARS-CoV-2 virus from a unique perspective, focusing on information entropy rather than the traditional concept of entropy.

“The physical entropy of a given system is a measure of all its possible physical microstates compatible with the macrostate,” Vopson explained in the paper. “This is a property of the microstates in the system that do not carry any information.” Given the same system and the ability to generate N information states within it (such as by encoding digital bits), creating N information states results in the formation of N extra information microstates that overlap with the existing physical microstates. These extra microstates contain valuable information, and the increase in entropy they bring is known as information entropy.”

According to Vopson, there is a tendency for entropy to increase over time, but interestingly, information entropy tends to decrease. Consider the heat death of the universe, where the entire cosmos eventually reaches a state of thermal equilibrium. At this stage, the maximum value of entropy has been attained, although not in terms of information entropy. During heat death (or just before), the temperature range and potential states in any part of the universe become extremely limited. As a result, the number of possible events decreases and the amount of superimposed information decreases, leading to a decrease in information entropy.

Although it may offer an intriguing perspective on the universe, can it provide us with any novel insights, or is it merely a secondary and insignificant approach to describing entropy? According to Vopson, the concept has the potential to be a fundamental law that could impact a wide range of fields, including genetics and the evolution of the universe.

“Based on my research, it seems that the second law of infodynamics is an essential principle in cosmology.” According to Vopson’s article in The Conversation, this has broad applicability and significant scientific implications. “It is understood that the universe undergoes expansion while maintaining a constant total entropy, without any heat loss or gain.” However, it is important to note that entropy always increases according to the principles of thermodynamics. This indicates the presence of an additional form of entropy, namely information entropy, that serves to counterbalance the increase.

With the expertise of a seasoned scientist, Vopson observed the ever-changing SARS-CoV-2 virus throughout the course of the COVID-19 pandemic. Regular sequencing of the virus has been conducted to closely monitor its changes, primarily with the aim of developing new vaccines. Examining the RNA instead of DNA, he discovered a gradual decrease in information entropy.

One fascinating example of a rapidly mutating organism is a virus. According to Vopson, the pandemic has provided an exceptional opportunity for research, with the numerous variants of SARS-CoV-2 serving as an unprecedented test sample. The amount of data available is truly remarkable, as stated in a press release.

The COVID data provides strong evidence for the second law of infodynamics, and this research has the potential to unlock countless possibilities. Imagine examining a specific genome and determining the potential benefits of a mutation before it occurs. This technology has the potential to revolutionize various fields, such as genetic therapies, the pharmaceutical industry, evolutionary biology, and pandemic research.

According to Vopson’s perspective, this implies that mutations are not haphazard but rather subject to a governing principle that dictates that information entropy should either remain constant or decrease over time. If this discovery is verified, it would be truly remarkable, as it challenges our current understanding of evolution. Vopson draws attention to a previous experiment conducted in 1972, where a virus unexpectedly experienced a decrease in its genome over 74 generations under optimal conditions. He argues that this observation aligns with his second law of infodynamics.

“Mutations occur randomly and are then subject to natural selection, which determines their impact on an organism,” he explained. What if there’s an underlying process that fuels these mutations? Whenever we encounter something beyond our comprehension, we tend to label it as ‘random’, ‘chaotic’, or ‘paranormal’, when in reality, it is simply our own limitation in explaining it.

By adopting a deterministic perspective, we have the potential to harness the laws of physics to anticipate and forecast genetic mutations, or even their likelihood, prior to their occurrence.

Vopson suggests that the law could potentially provide an explanation for the prevalence of symmetry in the universe.

“A high level of symmetry is associated with a state of low information entropy, which aligns with the requirements of the second law of infodynamics,” stated Vopson in his paper. “Therefore, this fascinating observation seems to provide an explanation for the prevalence of symmetry in the universe; it can be attributed to the influence of the second law of information dynamics.”

The audacious assertions (with their need for additional evidence) don’t end there.

“According to Vopson in The Conversation, the second law of infodynamics is a cosmological necessity and seems to have a universal application. This suggests that the entire universe might be a simulated construct or a massive computer.”

“In order to efficiently run a simulation of our incredibly complex universe, it would be necessary to incorporate data optimization and compression techniques. This would help reduce the computational power and data storage requirements needed for the simulation.” This is precisely what we see happening everywhere, from digital data and biological systems to mathematical symmetries and the vast expanse of the universe.”

Confirmation of the “second law of infodynamics” wouldn’t necessarily imply that we are living in a simulation. It’s important to consider that the theory could still hold true even if that scenario isn’t the case. There are additional quantum mechanical effects that seem to indicate that we are not.

So, what are the next steps for testing this further? According to the principles of infodynamics, it is believed that information possesses mass, enabling it to interact with all other entities. There are indications that this might be true, as suggested by a study conducted in 2012 that found that irreversible erasure of information seems to release heat. According to Vopson’s findings, it suggests that this energy needs to be converted into mass before it can be erased, essentially treating information as a distinct form of matter that is on par with mass and energy.

Experimentally determining whether information possesses mass may not pose a significant challenge. Performing a basic experiment involves measuring the mass of a hard drive both before and after irreversible information erasure. Regrettably, our current capabilities are insufficient to handle the minute mass change anticipated.

However, if this theory holds true, it is highly probable that elementary particles would contain valuable self-information, as suggested by Vopson. For example, consider the fascinating process of informing an electron (perhaps the sole electron in the entire universe) about its unique characteristics, such as its charge and spin. An interesting experiment involves colliding particles and antiparticles at high velocities.

“The experiment entails eradicating the information stored within elementary particles by allowing them and their antiparticles (mirror images of the particles with opposite charge) to annihilate, resulting in a burst of energy known as ‘photons’ or light particles,” explained Vopson. “I have accurately determined the anticipated range of frequencies for the photons that will be produced using principles from information physics.”

Although the concept may not align with conventional thinking, the experiment comes at a relatively affordable price of $180,000 (which is insignificant for advocates of simulation theory like Elon Musk) and can be tested using existing technology. Indeed, it may provide valuable insights into the validity of the concept. Exploring this idea could prove to be intriguing, as we aim to either dismiss it or determine its significance in terms of mass.

As Editor here at GeekReply, I'm a big fan of all things Geeky. Most of my contributions to the site are technology related, but I'm also a big fan of video games. My genres of choice include RPGs, MMOs, Grand Strategy, and Simulation. If I'm not chasing after the latest gear on my MMO of choice, I'm here at GeekReply reporting on the latest in Geek culture.


A new syndrome linked to COVID that could be fatal has appeared





There is a new outbreak of a rare but deadly autoimmune disorder in the north of England. New research suggests that the outbreak may be linked to COVID-19. Anti-MDA5-positive dermatomyositis is the name of the disease. It was mostly found in Asian people before the pandemic, but now it’s becoming more common among white people in Yorkshire.

Antibodies that target the MDA5 (melanoma differentiation-associated protein 5) enzyme are what cause the illness. It is linked to progressive interstitial lung disease, which scars lung tissue. Between 2020 and 2022, doctors in Yorkshire reported 60 cases of MDA5 autoimmunity, which was the highest number ever. Eight people died as a result.

What the researchers found when they looked at this sudden rise in cases is that it happened at the same time as the main waves of COVID-19 infections during the pandemic’s peak years. This caught their attention right away because MDA5 is an RNA receptor that is very important for finding the SARS-CoV-2 virus.

The study authors write, “This is to report a rise in the rate of anti-MDA5 positivity testing in our region (Yorkshire) in the second year of the COVID-19 pandemic. This was noteworthy because this entity is not commonly found in the UK.” They say this is likely a sign of “a distinct form of MDA5+ disease in the COVID-19 era.” They have named it “MDA5-autoimmunity and Interstitial Pneumonitis Contemporaneous with COVID-19” (MIP-C).

The researchers used tools that look for shared traits among people in the same medical cohort to figure out how this newly discovered symptom works. In this way, they found that people who had MDA5 autoimmunity also tended to have high levels of interleukin-15 (IL-15), a cytokine that causes inflammation.

The author of the study, Pradipta Ghosh, said in a statement that IL-15 “can push cells to the brink of exhaustion and create an immunologic phenotype that is very, very often seen as a hallmark of progressive interstitial lung disease, or fibrosis of the lung.”

Overall, only eight of the 60 patients had tested positive for COVID-19 before. This means that a lot of them may have had infections that didn’t cause any symptoms that they weren’t aware of. This means that even mild infections with no early symptoms might be enough to cause MDA5 autoimmunity.

The researchers say, “Given that the highest number of positive MDA5 tests happened after the highest number of COVID-19 cases in 2021 and at the same time as the highest number of vaccinations, these results suggest an immune reaction or autoimmunity against MDA5 after exposure to SARS-CoV-2 and/or vaccines.”

Ghosh says that the event probably isn’t just happening in Yorkshire. Reports on MIP-C are now coming in from all over the world.

The study was written up in the eBioMedicine journal.

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Medicine and Health

The largest-ever 3D-mapped segment of the human brain remains small enough to fit on a grain of rice





This vibrant spectrum of cells depicts the most extensive and detailed three-dimensional map ever created of a specific region of the human brain. Although it is the largest, it is still only a cubic millimeter in size, which is approximately equivalent to half a grain of rice. Through this achievement, scientists are now able to observe the complex network of 57,000 cells, linked by 150 million synapses and numerous millimeters of blood vessels, which constitute this particular small area of the human cortex.

Over the past ten years, a partnership between scientists at Harvard University and Google has been dedicated to creating a comprehensive and detailed map of the mouse brain. This represents a significant and crucial advancement in our progress, as it unveils the previously unknown intricacy of a portion of brain matter at the level of synapses.

Senior author Jeff Lichtman stated that the term ‘fragment’ is ironic. His team generated electron microscopy images that serve as the foundation for the new map. “For the majority of individuals, a terabyte is considered to be enormous. However, even a small portion of the human brain, which is minuscule and tiny, still contains thousands of terabytes.”

Using AI algorithms created by Google Research, the imaging from Lichtman’s team at Harvard can be color-coded and reconstructed to unveil unparalleled levels of detail.

It is reasonable to assume that neurons, which are the fundamental nerve cells, would be the most prevalent in the primary organ of the central nervous system, as indicated by their name, correct? However, the team discovered that the number of these cells was actually twice as many as the supporting glial cells, which play a role in maintaining the optimal environment of the brain. The oligodendrocytes, which generate myelin, the crucial insulation surrounding nerve axons, were the most abundant cell type.

The tissue fragment displayed peculiarities such as robust neurons interconnected by 50 or more synapses each, enlarged axons containing what the research team referred to as “unusual material,” and a limited quantity of axons arranged in “extensive whorls.” Due to the fact that the tissue sample was obtained from a patient with epilepsy, it remains uncertain whether these characteristics are associated with the aforementioned condition or not.

Mapping down to this level of detail is crucial because it has the potential to offer future researchers valuable insights into the impact of small-scale connections within brain tissue. These connections may have significant effects on major functions and contribute to the development of diseases.

The scientific field that studies the connections within the brain is referred to as “connectomics.”. Recent advancements in the field include a large-scale global initiative to comprehensively map the intricate connections within the human brain, similar to how we have mapped the human genome. Additionally, the first comprehensive map of an insect brain has been published.

In addition to previous achievements such as last year’s unveiling of a brain cell atlas, scientists can now delve into our intricate network of “little gray cells” with unprecedented depth.

In order to advance this objective and increase the accessibility of these techniques to a wide range of scientists, the Harvard and Google teams have created a set of analytical tools that are openly accessible to the public. “Due to the substantial investment made in this project, it was crucial to present the findings in a manner that allows anyone else to easily access and derive advantages from them,” stated Viren Jain, a member of the Google Research team.

The ultimate objective of this project is to create a comprehensive map of the entire mouse brain. This map will yield approximately 1,000 times more data than what is currently being generated from this 1-cubic-millimeter fragment of the human brain. Therefore, there is still a considerable amount of progress to be made.

The authors acknowledge that approaches to understanding the meaning of neural circuit connectivity data are still in their early stages. However, they consider this petascale dataset as a starting point.

The research findings have been published in the scientific journal Science.

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Medicine and Health

A cutting-edge brain implant has been developed that can accurately translate imagined speech in real time, achieving the highest level of precision to date





Caltech bioengineers’ new tool has proven to be exceptionally adept at deciphering brain signals related to internal speech. Although it has only been tested in two patients thus far, with further development, this technology has the potential to enable individuals who cannot speak to communicate solely through their thoughts.

BMIs are already achieving remarkable feats. These systems have been utilized to assist paralyzed patients in walking and, in the case of Neuralink’s first experimental subject, enable them to control a computer through a “telepathic” connection.

One of the primary applications of this technology involves facilitating communication. For people who are unable to speak, such as those with neurological conditions or brain injuries, BMIs can give them a voice.

There are some limitations to devices of this kind, like the one that the late Stephen Hawking famously used. One challenge is capturing the natural rhythm of speech, which scientists are actively researching, aided by Pink Floyd. Another limitation is that many speech BMIs rely on users attempting to vocalize words, which may not be feasible for everyone. An optimal solution would involve discovering a method to decipher internal speech, allowing individuals to simply imagine uttering a word. Progress in this field has been made, but it has been quite difficult, and the outcomes have been varied.

Now, the team at Caltech has created a system that can accurately decode internal speech with unprecedented precision.

Microelectrode arrays were surgically inserted into the brains of two male patients who were experiencing tetraplegia, one aged 33 and the other aged 39. The team focused on the primary somatosensory cortex and the supramarginal gyrus (SMG), a brain region that has not been investigated in previous studies on speech BMI.

The interface was trained on a combination of real and made-up words to determine their impact on the system’s effectiveness. The participants were presented with each word either visually or audibly and were subsequently instructed to mentally simulate saying the word for a duration of 1.5 seconds. They were then requested to vocalize the word.

According to first author Sarah Wandelt, this technology would be especially beneficial for individuals who have lost their ability to move. For example, let’s consider a condition such as locked-in syndrome.

Using the BMI, the researchers were able to analyze the real-time activity in the SMG while the participants were contemplating each word. One participant achieved an accuracy of 79 percent, which is comparable to the accuracy of decoding vocalized speech, according to Wandelt and co-author David Bjånes. The other participant, however, only achieved an accuracy of 23 percent.

The technology will require additional refinement and testing on a larger sample size with a broader range of words. However, the study does indicate that the SMG shows promise as a brain region to focus on.

“Although the second participant did not replicate these results, this study holds significance as it is, to my knowledge, the first successful implementation of a real-time speech brain-computer interface using single unit recordings in the SMG,” remarked Blaise Yvert of The Grenoble Institute of Neuroscience, who was not part of the study.

Additionally, the team is interested in exploring whether the BMI can effectively differentiate between different letters of the alphabet. Wandelt and Bjånes propose that decoding individual sound units of speech, known as phonemes, may offer a potential avenue for investigation.

According to Giacomo Ariani, the Associate Editor of the paper, this proof-of-concept study on high-performance decoding of internal speech will undoubtedly capture the attention of researchers who are dedicated to advancing the capabilities of BMIs and other therapeutic devices for individuals who have lost their ability to speak.

The study has been published in the prestigious journal Nature Human Behavior.

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