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Neurological implant aids paralyzed individual in regaining speech abilities in two distinct languages

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A solitary cerebral implant has been employed to facilitate the restoration of speech in a paralyzed individual, encompassing both his mother tongue, Spanish, and the English language. Despite acquiring English at a later stage in life, the brain-computer interface (BCI) successfully detected the language he attempted to speak without requiring pre-programming. It is plausible that this capability could be even more effective for individuals who have been bilingual for a significant portion of their lives.

The individual, who was 36 years old, experienced quadriplegia as a result of a stroke that impacted a section of the brainstem. Remarkably, it was at the age of 30, following the stroke, that he attained a high level of proficiency in English, which was his second language. This is in spite of receiving a diagnosis of anarthria from a speech-language pathologist. Although his cognitive functions remained intact, his ability to control his vocal tract was limited, allowing him to only produce grunts and moaning sounds rather than coherent words.

The man had been utilizing an interface that allowed him to form words by making slight movements with his head, but the implementation of a brain-computer interface (BCI) had the capacity to significantly enhance this.

Prior research has demonstrated the profound and revolutionary effects that this technology can bring about. Recently, researchers presented preliminary findings on a system designed to restore speech to individuals who lack physical control over their vocal abilities. Alternative systems exist that assist individuals in computer typing by simulating the act of handwriting. Neuralink, a company led by Elon Musk, has recently implanted its inaugural brain-computer interface (BCI) device, which is purported to function akin to “telepathy.”.

The bilingualism of the participants in this trial introduced an additional level of intrigue.

The authors state in their paper that it is still uncertain to what degree bilingual speech production depends on distinct or overlapping cortical activity between languages. Consequently, it was uncertain whether a solitary device could accurately interpret neural signals when the individual was attempting to communicate in both English and Spanish.

The successful surgical procedure for implantation occurred more than three years ago. The device comprises a grid of 128 electrodes and was affixed to the surface of the patient’s left hemisphere, specifically targeting regions that play a crucial role in speech production. The device can be connected to a computer system through a connector that is implanted in the skull.

The implant functions by interpreting the neural signals that typically indicate the intention to articulate a specific word, which would normally be transmitted to the facial muscles and vocal tract. There is evidence suggesting that when acquiring a second language, the brain integrates it with the existing speech patterns of the native language. The authors of the study hypothesized that the similarities between English and Spanish in the man’s brain could enable the implant to generate either language.

However, the act of implanting the hardware is merely one component of this process. The software required training as well. Initially, they possessed a restricted lexicon consisting of 51 English words, 50 Spanish words, and three words that were shared between both languages, such as the man’s moniker, Pancho. During the training session, the participant will be presented with words individually on a screen. Subsequently, the participant will be required to verbally articulate the words in order for the system to accurately interpret their brain activity.

In order to facilitate progress, the researchers utilized the advancements observed in large language models by inputting the system’s output into GPT2. This contributed to a decrease in the error rate.

Following extensive training, the ultimate assessment was to determine whether the participant could effectively utilize the system to engage in a conversation utilizing the pre-established vocabulary. It was demonstrated to be feasible by the authors in Supplementary Video 3, and the individual was capable of effortlessly transitioning between languages.

Although the system has a limited vocabulary and requires regular recalibration through ongoing training, it has lasted longer than some other systems, reaching a duration of 48 days. This provides an exciting glimpse into the potential achievements of this developing technology. Furthermore, it contributes to our understanding of the mechanisms underlying bilingualism in the brain.

An ideal system would possess enhanced versatility, enabling users to seamlessly transition between languages, even within a single sentence. The authors express a positive outlook regarding their technology, stating that it has the capability to enhance communication for bilingual individuals with paralysis, who may find it advantageous.

The research findings have been published in the esteemed scientific journal Nature Biomedical Engineering.

As Editor here at GeekReply, I'm a big fan of all things Geeky. Most of my contributions to the site are technology related, but I'm also a big fan of video games. My genres of choice include RPGs, MMOs, Grand Strategy, and Simulation. If I'm not chasing after the latest gear on my MMO of choice, I'm here at GeekReply reporting on the latest in Geek culture.

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Medicine and Health

As a possible world first, Finland will give bird flu vaccines to groups that are most likely to get sick

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Inland is poised to become the first nation globally to administer prophylactic avian influenza vaccines to select individuals. According to reports, the European Union (EU) has obtained the initial deliveries of the vaccine, which will be sent to the EU. This is to ensure that individuals who are most vulnerable to the virus can receive some level of protection.

According to Reuters, the European Union (EU) is set to enter into a contract with CSL Seqirus, a vaccine maker, to obtain 665,000 doses of a preventive avian influenza vaccine. This contract will be on behalf of 15 nations within the EU and the European Economic Area (EEA). Similar initiatives are already in progress in the United States, Canada, and the United Kingdom. However, considering that the European Union’s agreement is scheduled to be finalized on June 11, 2024, it appears highly probable that Finland will be the first country to commence its immunization campaign.

The Zoonotic Influenza Vaccine Seqirus, approved by the European Medicines Agency (EMA) in October 2023, was specifically designed to combat a strain of avian influenza classified as H5N8.

This is distinct from the avian influenza that has recently received attention as a result of outbreaks on dairy farms in a number of US states, specifically due to the H5N1 virus. The vaccine does focus on the hemagglutinin surface protein of the virus, specifically the “H” part that is shared by both H5N8 and H5N1, so it is expected to offer some protection against H5N1.

Currently, there have been three instances where agricultural workers in the US have become infected with the virus due to contact with cows that were carrying the infection. However, there is no evidence to suggest that the virus can be transmitted between individuals. Although the overall risk is typically deemed to be minimal, those who have vocations that include close interaction with animals will serve as early indicators if this virus begins to transmit more frequently to people.

The US Centers for Disease Control and Prevention (CDC) advise those who are in close proximity to dairy cows or raw milk to maintain proper hand hygiene and utilize personal protection equipment such as gloves, respirators, and safety goggles. It is anticipated that a vaccination, even targeting a slightly variant strain of avian flu, will provide an additional level of defense.

As of now, no nations in the European Union (EU) or European Economic Area (EEA) have reported any instances of H5N1 infection in humans. The European Centre for Disease Prevention and Control stated in its weekly report for June 1–7 that the likelihood of zoonotic influenza spreading to the general public in EU/EEA nations is deemed to be minimal.

In 2023, Finland saw many occurrences of extremely contagious H5N1 infections. These outbreaks affected both wild birds and mammals on numerous fur farms around the country, leading to the need for extensive culling.

Farmed animals, such as mink, are prone to the avian flu. However, the occurrence of outbreaks on fur farms and the current situation with dairy cows in the US are particularly worrying to epidemiologists. This is because it raises the possibility of continuous transmission between mammals, which in turn increases the likelihood of a virus crossing over to humans.

According to Hanna Nohynek, the head of the Infectious Diseases Control and Vaccines Unit at the Finnish Institute for Health and Welfare, “the situation appeared highly concerning last year,” according to Euractiv. “Although this year has been relatively peaceful, we are aware that the virus is still present based on the situation in the United States. Therefore, our aim is to safeguard individuals who are involved in handling animals that could potentially be impacted.”

According to STAT News, Finnish officials intend to promptly distribute vaccination doses to chicken farmers, fur farm workers, veterinarians, and virus researchers once the vaccines arrive in the country.

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The Roman Baths in England are renowned for their potential medicinal properties

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New research has indicated that the thermal waters of the famous Roman Baths in the city of Bath, England, may provide a solution to fighting antibiotic resistance. By isolating over 300 distinct microorganisms residing in the warm pools of the renowned attraction, the researchers found that 15 of these have the ability to impede certain highly concerning disease-causing agents.

Antimicrobial resistance is a significant and continuously escalating concern, projected to result in approximately 1.27 million fatalities annually worldwide. It is anticipated that this yearly toll would escalate to 10 million by the year 2050. Currently, the search for novel natural antibiotics is considered our most promising solution to counteract the increasing danger. However, efforts to uncover such items have mostly been fruitless thus far.

In order to look for these new compounds that might kill bacteria, scientists are now placing more emphasis on extreme habitats like hot springs. This is because the unusual ecosystems present in these conditions are likely to harbor distinct creatures that might possess antimicrobial characteristics.

The researchers chose to examine the microbial communities in the water, biofilm, and sediment at specific locations within the Roman Baths. These locations include the King’s Spring, where the water temperature reaches approximately 45 °C (113 °F), and the slightly cooler Great Bath, which has a temperature of around 30 °C (86 °F). The Roman Baths are unique in the UK as they are the only place with a thermal spring.

In total, the researchers successfully identified and separated 297 unique bacterial species, including many strains of Actinobacteria and Myxococcota, which are well-known for their ability to produce antibiotics. Upon initial screening, it was shown that 92 of these substances exhibited different degrees of activity against the pathogens E. coli and Staphylococcus aureus.

Subsequently, these highly potential candidates underwent testing against the remaining six bacteria that constitute the ESKAPE pathogens. These pathogens are deemed by the World Health Organization to be in critical need of innovative antibiotic therapies. In total, 15 of the samples collected from the Roman Baths exhibited “broad spectrum activity,” meaning they were effective against three or more of these diseases.

Dr. Lee Hutt, the study author, stated that these studies have shown, for the first time, the presence of some microbes in the Roman Baths. This discovery suggests that the Roman Baths could be a valuable source for developing new antimicrobial substances.

“It is quite ironic that the waters of the Roman Baths have been historically recognized for their medicinal qualities, and now, with the progress of modern science, we may be close to confirming that the Romans and subsequent civilizations were indeed correct,” he remarks.

The research is published in the scientific publication named The Microbe.

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Medicine and Health

What is the medical condition known as “gamer’s thumb”?

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The global popularity of video games and e-sports is steadily increasing, resulting in a growing number of individuals of different age groups engaging in gaming. Nevertheless, this increase in popularity and acceptance may bring about several lesser-known issues. While gaming may not directly affect our health, it nonetheless places physical demands on our bodies.

Indeed, while gaming and e-sports may not need the same level of physical exertion as conventional sports, they can nonetheless result in injuries due to repetitive strain. An example of this is a condition known as “gamer’s thumb”.

While the term “gamer’s thumb” may suggest that it only affects individuals who play computer games, it is not exclusive to gamers. However, individuals who engage in repetitive thumb movements, such as excessive texting or typing, or frequently lifting heavy objects, are susceptible to developing this condition. For gamers and e-sports participants, regardless of whether they are using a console, PC, or mobile phone, the extensive amount of time spent engaging with keyboards, twisting, and grasping may render them susceptible to this issue.

The condition is formally referred to as “de Quervain’s tenosynovitis”. This condition is classified as an overuse injury, akin to carpal tunnel syndrome and trigger finger. It results in inflammation of the tendons in the thumb and the protective covering that surrounds them. It is believed that this is caused by the repetitive motion associated with grabbing, clenching, and pinching, which leads to the thickening of the tendon and difficulty in its smooth movement within its protective covering.

Repeated movement might result in discomfort and sensitivity near the thumb’s base. Occasionally, there may be concomitant pain on the radial side of the wrist, which is the side where the thumb is located. Certain individuals may also encounter challenges in mobilizing their thumb, particularly when attempting to grip or squeeze an object.

Once the sensation of pain arises, it has the potential to significantly disrupt routine tasks and responsibilities. Engaging in activities such as lifting goods or executing seemingly uncomplicated actions like loosening jar lids might result in discomfort.

Untreated, the pain may eventually hinder your gaming performance and enjoyment, as it affects both your ability to move and the level of pain you experience.

If you are experiencing symptoms similar to these, it is advisable to seek medical assistance. Procrastinating on addressing the issue can exacerbate its severity. Occasionally, the discomfort can extend to the thumb or forearm, and movement may also become more agonizing.

During the examination, your doctor will probably assess the thumb and wrist and may require an X-ray of the hand and wrist region. If the diagnosis is confirmed, the treatment will primarily aim to alleviate pain and restore the functionality of the hand and wrist. If the condition is extremely serious, a medical professional may advise undergoing a surgical procedure.

Non-invasive therapies encompass the administration of anti-inflammatory drugs to alleviate swelling and discomfort. In certain instances, corticosteroid injections can be considered as an alternative, effectively reducing both pain and inflammation. A physician may also advise immobilizing the thumb and wrist region using a brace or splint, since this will aid in preventing additional irritation to the affected area.

Treatment for “gamer’s thumb” is often basic and effective. Nevertheless, the most effective approach to prevent the problem is to refrain from engaging in extended periods of gaming and to incorporate intervals of rest between gaming sessions. This will aid in the prevention of injuries and enable you to fully enjoy gaming without any complications.

This essay does not aim to replace professional medical advice, diagnosis, or treatment. It is always advisable to consult certified healthcare professionals if you have any inquiries about medical concerns.

 

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