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A hydrogel bonding method developed by Harvard University opens up possibilities for novel biomaterials solutions

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An innovative method for the rapid and effective adhesion of hydrogels has the potential to greatly advance the progress of creating new biomaterials, meeting many unmet therapeutic needs.

The versatility of hydrogels has led to their growing prevalence in diverse biomedical domains. Biomaterials, composed of water-swollen molecular networks, can be tailored to mimic the mechanical and chemical properties of various organs and tissues. This enables individuals to engage with both the internal and external surfaces of the human body without causing harm to even the most fragile regions of human anatomy.

In clinical practice, hydrogels are currently employed for the purpose of therapeutically delivering medications to combat pathogens. Additionally, they find application in ophthalmology as intraocular and contact lenses, as well as corneal prostheses. Furthermore, hydrogels find utility in bone cement, wound dressings, blood-coagulating bandages, and 3D scaffolds within the field of tissue engineering and regeneration.

Nevertheless, the rapid and robust attachment of hydrogel polymers to each other has remained an unresolved and unmet requirement. Conventional approaches frequently yield diminished adhesion during prolonged adhesion durations and necessitate intricate procedures. The rapid adhesion of polymers has the potential to facilitate various new applications. These include the development of hydrogels with adjustable stiffness to better fit specific tissues, the ability to encapsulate flexible electronics on demand for medical diagnostics, and the creation of self-adhesive tissue wraps for difficult-to-bandage body parts.

Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University and the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a straightforward and adaptable technique for rapidly and efficiently joining layers composed of hydrogels and other polymeric materials. This method involves the utilization of a thin layer of chitosan, a fibrous, sugar-based substance obtained from the processed outer skeletons of shellfish. Their new method worked well to solve a number of unresolved medical problems, including cooling tissues precisely, sealing vascular lesions, and stopping “surgical adhesions” between internal body surfaces that are not wanted. According to the Proceedings of the National Academy of Science, the results have been published.

According to David Mooney, Ph.D., a senior author and Founding Wyss Institute Core Faculty member, chitosan films possess the capacity to efficiently assemble, finely adjust, and safeguard hydrogels within the human body and other environments. This presents a multitude of novel prospects for the development of devices in the fields of regenerative medicine and surgical care. “Their high versatility as tools and components for in vivoassembly processes in surgeries, as well as the fabrication of complex biomaterial structures in manufacturing facilities, is due to their speed, ease, and effectiveness.” At SEAS, Mooney holds the esteemed position of Robert P. Pinkas Family Professor of Bioengineering.

Developing a novel bond

In recent years, Mooney’s team at the Wyss Institute and SEAS has created a set of regenerative medicine techniques called “Tough Adhesives.” These techniques involve the use of stretchable hydrogels to promote wound healing and tissue regeneration. They achieve this by firmly adhering to wet tissue surfaces and adapting to the mechanical properties of the tissues. The development of precisely made tough adhesives and non-adhesive hydrogels presents novel prospects for enhancing patient care, both for ourselves and other researchers. “However, in order to enhance their capabilities to a greater extent, our objective was to integrate multiple hydrogels into intricate structures and to accomplish this efficiently, securely, and through a straightforward procedure,” stated Benjamin Freedman, Ph.D., co-first author and former Wyss Research Associate, who led various advancements in Tough Adhesive alongside Mooney. We now know that the current methods for quickly bonding hydrogels or elastomers have major problems because they rely on dangerous adhesives, changing the chemicals on the surfaces of the materials, or other complicated steps.

The team utilized a biomaterial screening method to identify bridging films composed entirely of chitosan. Chitosan, a polymer with a high sugar content, can be readily synthesized from the chitin shells of shellfish and has already been extensively utilized in several industrial contexts. As an illustration, it is presently employed for seed treatment and as a biopesticide in the field of agriculture, as well as for the prevention of spoilage in winemaking, self-healing paint coatings, and medical wound management.

The researchers saw that chitosan films bonded with hydrogels more quickly and strongly than other methods. This is because they had different chemical and physical interactions than other methods. A slight pH change does not cause the sugar strands in chitosan to form new chemical bonds through mutual electron sharing (covalent bonds). Instead, they quickly absorb the water present between hydrogel layers and become entangled with the polymer stands of hydrogels. This leads to the formation of multiple bonds through electrostatic interactions and hydrogen bonding (non-covalent bonds). As a result, compared to conventional hydrogel bonding techniques, the adhesive forces between hydrogels are much stronger.

Initial applications

In order to showcase the extensive capabilities of their novel approach, the researchers focused their attention on a diverse range of medical obstacles. The researchers demonstrated that the incorporation of chitosan films into tough adhesives facilitated their application as self-adhering bandages, specifically designed for the purpose of enhancing wound care. The use of chitosan-bonded hydrogels, which have a high water content, enables local cooling of the underlying human skin. This has the potential to pave the way for alternative burn therapies in the future.

The hydrogels, which were modified with thin chitosan films, were effectively encased around colon, tendon, and peripheral nerve tissue by the researchers without establishing any direct bond with the tissues. This method presents the potential to efficiently isolate tissues from one another during surgical procedures, thereby preventing the formation of fibrotic adhesions that can lead to severe outcomes. According to Freedman, the prevention of this issue remains an unmet clinical need that commercial technologies are now unable to effectively address.

In a different scenario, a slender chitosan layer was applied over a durable gel that had been previously applied to a damaged pig aorta outside of the body. This improved the bandage’s overall toughness because it would be more resistant to the repeated mechanical pressures that the blood would apply inside the vessel.

According to Donald Ingber, M.D., Ph.D., the Founding Director of Wyss, who holds the positions of Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Children’s Hospital, as well as the Hansjörg Wyss Professor of Bioinspired Engineering at SEAS, the study conducted by Dave Mooney’s group presents a multitude of potential applications in the field of biomedical hydrogel devices. These advancements have the potential to address pressing unresolved issues in regenerative and surgical medicine, offering valuable solutions that could be beneficial to a significant number of patients.

As Editor here at GeekReply, I'm a big fan of all things Geeky. Most of my contributions to the site are technology related, but I'm also a big fan of video games. My genres of choice include RPGs, MMOs, Grand Strategy, and Simulation. If I'm not chasing after the latest gear on my MMO of choice, I'm here at GeekReply reporting on the latest in Geek culture.

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Boston Dynamics has retired its Atlas robot, showcasing its most impressive moments

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Boston Dynamics is discontinuing its hydraulic robot Atlas after years of pushing the limits. In order to bid adieu, the innovative firm has compiled a film montage showcasing the most remarkable instances of the mechanoid marvel, encompassing comical dancing routines, impressive acrobatic maneuvers, and a handful of unsuccessful attempts.

Atlas has been a source of inspiration for nearly ten years, igniting our creativity, motivating future generations of roboticists, and surpassing technical obstacles in the area. Boston Dynamics stated in a video aired on April 16 that it is now time for their hydraulic Atlas robot to rest and unwind.

“Please review all the achievements we have made so far with the Atlas platform,” they added.

Boston Dynamics, a robotics company based in Massachusetts, created Atlas for the Defense Advanced Research Projects Agency (DARPA), the Pentagon’s advanced technology division. Initially, it was conceived as a component of a prize competition with the aim of accelerating the progress of a humanoid robot capable of aiding in search and rescue missions.

Upon its public introduction in 2013, Atlas required a tether for stability and was limited to walking in a linear path. Almost.

A 1-year-old youngster has limited ability to walk and frequently stumbles. “As you observe these machines and draw comparisons to science fiction, it is important to bear in mind that this represents our current technological capabilities,” stated Gill Pratt, a program manager at DARPA who was involved in the design and funding of Atlas, in an interview with the New York Times in 2013.

Significant transformations have occurred since that time. The engineers at Boston Dynamics have meticulously tweaked the robot’s technology and algorithms throughout its development, enabling it to carry out physical tasks that would be difficult for most people with ease.

The most recent version of Atlas has a height of 150 cm, which is a little less than 5 feet, and a weight of 89 kilograms, equivalent to 196 pounds. With the help of its 28 hydraulic joints, this machine can achieve speeds of up to 2.5 meters (nearly 8 feet) per second. Additionally, it is capable of executing somersaults, athletic jumps, and 360° spins.

Additionally, it is equipped with a multitude of sensors that are utilized to accurately sense the immediate surroundings and respond accordingly in real-time. For example, if an obstacle is placed in the path of the robot, it will identify the issue and navigate around it. If you push it with a pole, it will elegantly adapt its body to stay upright.

Boston Dynamics has not provided an explanation for its decision to discontinue its renowned robot. Certain analysts have proposed that the corporation is preparing for the release of another novel product, but others have questioned whether Atlas has become a financial liability. While the company has successfully marketed its other inventions, such as the dog-like robot Spot, to different companies for diverse purposes, Atlas was never made available for sale.

According to IEEE Spectrum, Boston Dynamics has announced that they are retiring the hydraulic Atlas robot. Does this imply that a hydraulic Atlas robot is not the next item on the schedule? Currently, the outcome is uncertain and cannot be predicted.

It is uncertain what the future holds for the robots developed by Boston Dynamics, but we can only hope that it does not involve a rebellion by these machines.

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Boston Dynamics’ Atlas humanoid robot has transitioned to electric power

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Atlas is immobile, lying face down on a stack of connected gym mats. The only audio accompaniment is the humming of an electric motor. While it may not be completely silent, the noise level is significantly lower compared to the abrupt movements of its predecessors.

While the camera rotates, the robot’s legs flex at the knees. Initially, it is a spontaneous motion that gradually transitions into an eerie domain, reminiscent of scenes from a Sam Raimi film. The robot has successfully changed its position by cleverly rotating its legs, appearing as if it is lying on its back.

Atlas is positioned with its back facing the camera. Currently, the head rotates in a complete 180-degree motion, and subsequently, the torso mimics this movement. The object pauses briefly, allowing the camera to get a clear picture of its head—a circular screen with a ring-shaped light surrounding it. Once again, the torso rotates in alignment with the head’s 180-degree turn as Atlas moves away from the camera and exits the frame.

Boston Dynamics has recently announced that their humanoid robot, Atlas, has transitioned from a hydraulic system to an electric one, following in the footsteps of Bob Dylan.

The pace is rapid, with the steps still somewhat abrupt, although noticeably smoother than many of the recent commercial humanoids that have been introduced in the past few years. If anything, the gait evokes the bold self-assurance of Spot, a relative of Atlas who diverged from the humanoid lineage a few generations ago.

Brand new Atlas

The latest iteration of the robot is nearly indistinguishable. The top-heavy torso, bowed legs, and plated armor have been eliminated. There are no visible cables present on the sleek and slender new mechanical framework. The company, which has successfully defended against reactionary concerns about robopocalypse for many years, has chosen a more compassionate and considerate design compared to both the original Atlas and more modern robots such as the Figure 01 and Tesla Optimus.

The new robot’s appearance is more similar to that of Agility’s Digit and Apptronik’s Phoenix. The traffic-light-headed robot features a gentler and more whimsical design. According to the video, it is referred to as the “All New Atlas.” Boston Dynamics has deviated from its usual practice by retaining the research name for a product that it intends to market commercially. SpotMini was renamed Spot. The handle was transformed into a stretch. Currently, Atlas remains unchanged and is still referred to as Atlas.

“We may reconsider this when we are fully prepared to construct and distribute on a large scale,” states Boston Dynamics CEO Robert Playter in an interview with. “However, I believe that at present, it is beneficial to preserve the branding.”

The executive’s statement reveals the project is still in its initial phases. Boston Dynamics intends to start pilot testing of the electric Atlas at Hyundai facilities soon, with full-scale production following in a few years.

“Starting next year, we will be conducting on-site experiments with Hyundai,” states Playter. “We currently possess Hyundai equipment at our location.” We have been engaged in this task for a considerable period of time. In order to achieve success, it is imperative to possess a plethora of attributes beyond merely possessing innovative technology. In order to justify the investment in a robot, it is crucial to fully comprehend the use case and ensure that there is enough productivity to make it worthwhile.

Performing a complete reversal

The most remarkable aspect of the 40-second “All New Atlas” teaser is the robot’s motions. They serve as a reminder that constructing a humanoid robot does not necessitate maximizing its human-like qualities. Despite billions of years of evolution, as one investor pointed out in the past, humans have not yet perfected themselves as machines. If we are going to design machines that resemble us, why not construct ones that possess capabilities beyond our own?

“We have constructed a collection of bespoke actuators that are powerful and adaptable, installed at the majority of joints,” states Playter. “The range of motion is extensive.” The compact design of this robot effectively harnesses the strength and agility of an exceptional athlete, allowing us to utilize its capabilities in various applications.

It is important to remember that Boston Dynamics has built its reputation through a series of popular videos over the course of many years. New additions to the canon are equally likely to feature a robot’s dance moves as they are to offer anything truly practical in an industrial environment. Therefore, it is challenging to separate the features that the company considers genuinely functional from those that are merely intended to impress.

Commencing in the prone position, for example, provides an opportunity to demonstrate the impressive reverse crab leg maneuver while also serving a practical purpose. Boston Dynamics proudly demonstrated in the farewell video of the hydraulic Atlas that falling down is an inherent aspect of its function, as is the ability to recover and stand up again. In reality, the majority of the current generation of industrial robots necessitates human intervention in the event of a failure. Conversely, a robot that can autonomously remove dust from its surface and resume its tasks is highly advantageous for enhancing productivity.

The system’s agility significantly enhances its potential for productivity. It reminds me of Agility’s Digit demonstrations (the company is notably the only one of its kind demonstrating systems at this magnitude), in which a robot walks to a shelf, rotates, walks to the conveyor belt, rotates again, and walks back. When you multiply that task by hundreds, or even thousands, per day, you start to realize the importance of saving valuable seconds.

“It will possess a range of movements that surpass human capabilities,” Playter explains. “There will be highly utilitarian applications for that.”

Minimizing the robot’s turning radius is crucial in confined areas. These machines are intended to be brownfield solutions, meaning they are specifically designed to be seamlessly integrated into pre-existing workflows within existing spaces. Enhanced maneuverability could ultimately determine whether one can effectively operate in a particular environment or if the layout needs to be redone.

Cranium and upper extremities

The hands featured in the video are not newly created, as they have previously been used on the hydraulic model. However, they also signify the company’s choice to not strictly adhere to human design as a guiding principle. The distinction lies in the choice of using three fingers instead of four on the end effectors.

“A hand contains a great deal of intricacy,” states Playter. When using actuators to interact with the world, it is essential to anticipate and ensure both reliability and robustness. Therefore, we intentionally designed these objects with less than five fingers in order to manage and reduce their level of complexity. We are currently investigating various generations of individuals. We desire a grasping mechanism that adheres to regulations and is capable of adjusting to various shapes while possessing advanced sensing capabilities to accurately detect contact.

Internally, the head is likely the most controversial element of the design. The large, circular screen bears resemblance to a vanity mirror.

“It was a design element that we were greatly concerned about,” says Playter. “All the other individuals possessed a humanoid form.” I desired it to be distinct. We desire a welcoming and inclusive atmosphere. It offers a range of colors for a visual presentation. Undoubtedly, the object contains concealed sensors, but its design primarily aims to convey a sense of amicability. That knowledge will be crucial for effectively engaging with these entities in the future.

A Christmas Atlas

The landscape has undergone significant changes in the past decade since the hydraulic Atlas was first introduced. There are several other companies, such as Figure, Apptronik, Tesla, and 1X, that also have humanoid robots like Electric Atlas.

There has been a significant increase in interest from our end. Three significant events, in my opinion, are what have caused the increase. Hyundai paid almost one billion dollars to acquire Boston Dynamics. That really caught everyone’s attention, making them realize there was a way out. Tesla’s expression of interest in manufacturing has confirmed the validity of our long-standing efforts. Furthermore, the rise of AI as a valuable tool in addressing general challenges is making all of this possible. We have taken our time to make this announcement, as we wanted to conduct thorough research to ensure that we can effectively address manipulation issues and have full confidence in our new generation of machines.

Despite Boston Dynamics’ significant advantage in the field of humanoids, Playter mentions that the company managed to assemble the initial version of the new robot around Christmas 2023. Prior to that, it was addressing numerous intricate issues in simulation.

This week, it appears that the company is prepared to showcase the capabilities of the robot, or at least provide a glimpse into its initial plans for the system.

Intelligence in a broad sense
One thing that can be said about Elon Musk is that he consistently makes ambitious commitments. During the initial stages of Optimus’ public debut, when the Tesla ‘bot seemed to resemble a human in spandex, the executive discussed a comprehensive system capable of performing various tasks. Imagine having an Optimus that can handle your factory work, run errands, and even prepare a delicious dinner for you. That’s the aspiration, isn’t it?

The reality is, of course, one that is built upon taking small steps forward. Robotics companies are currently engaged in discussions about “general-purpose humanoids,” but their systems are currently focused on scaling one task at a time. For many individuals, the primary objective is to transport payloads from one location to another. To fully leverage the form factor, a broader level of intelligence will be necessary.

The app store model seems to offer the most straightforward solution. Developer access has indeed played a significant role in expanding Spot’s range of features. According to Playter, Boston Dynamics has a different approach in mind for Atlas.

“We will focus on developing an application rather than creating a platform,” he states. In our experience, the key to making progress quickly is to prioritize a specific application and actively work towards solving any challenges that arise. We cannot rely on others to solve these problems for us. I believe that AI is a crucial component in this context. To ensure the efficiency of tasks, they will be enhanced with AI techniques.

Developers now have access to Spot’s reinforcement learning algorithm, thanks to the company’s recent decision. This work will be crucial for Atlas’ expanding skillset.

Thinking creatively

In order to achieve success, Playter emphasizes the importance of thinking outside the box.

“I believe there are numerous other robots capable of accomplishing that,” he remarks. Humanoids should be capable of handling a wide range of tasks. You have two hands. As a business owner, you need to be able to handle intricate and heavy geometric shapes that a basic box picker wouldn’t be able to manage. And you have to handle a massive volume of these shapes, numbering in the hundreds of thousands. I believe the era of the single-task robot is long gone. Stretch is a unique application where a robot can efficiently navigate and handle boxes.

What other responsibilities will the new Atlas have on the Hyundai show floor, similar to those of a business owner? The company shared a video in February that contains the solution. The video shows the hydraulic version of the robot interacting with the Hyundai parts that Playter previously mentioned.

“With our extensive experience in the field of dynamic mobility, we possess the strength and expertise to handle substantial payloads while ensuring exceptional mobility,” he explains. Being able to handle heavy, complex, and massive objects will set us apart from the competition. The strut in the video likely weighs around 25 pounds. Acquiring wheels: we will be releasing a video later on as part of our comprehensive initiative, showcasing the various manipulation tasks we have been conducting with Atlas using real-world objects. I’m quite certain we have a good grasp on how to handle that aspect, and I haven’t observed anyone else attempting it thus far.

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Bionics

Scaling up semiconductors: A new processor provides a significant increase in problem-solving speed

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Annealing processors were specifically made to deal with combinatorial optimization problems, such as finding the best solution from a small set of possible outcomes. These findings have practical consequences for handling logistics, allocating resources, and identifying medications and commodities.

Within the realm of CMOS, a specific category of semiconductor technology, it is imperative that the constituent elements of annealing processors exhibit complete interconnection. Nevertheless, the intricacy of this interconnection has a direct impact on the scalability of the processors.

Professor Takayuki Kawahara from Tokyo University of Science has conducted a recent study in IEEE Access. The researchers have successfully created and evaluated a scalable processor that distributes the calculation across numerous LSI chips. On January 25, 2024, the idea was also showcased at the IEEE 22nd World Symposium on Applied Machine Intelligence and Informatics (SAMI 2024).

The goal, according to Professor Kawahara, is to develop sophisticated information processing capabilities at the edge rather than relying on cloud-based systems or performing preprocessing at the edge for cloud-based operations. It was possible to create a fully connected Large Scale Integration (LSI) on a single chip using 28nm CMOS technology with the aid of the distinctive processing architecture that the Tokyo University of Science introduced in 2020. Additionally, a scalable strategy made use of parallel-operating chips, and the use of Field-Programmable Gate Arrays (FPGAs) in 2022 demonstrated its viability.

The team created a scalable annealing processor. A total of 36 22nm CMOS calculation LSI (Large Scale Integration) processors and one control FPGA were employed in the system. This technological advancement facilitates the fabrication of extensive, interconnected semiconductor systems according to the Ising model, a mathematical framework for magnetic systems, encompassing a total of 4096 spins.

 

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