Bionics
Redwire Space produces human knee cartilage in space for the first time

Redwire Space has “bioprinted” a human knee meniscus on the International Space Station, which could treat Earthlings with meniscus issues.
The meniscus cartilage was manufactured on Redwire’s ISS BioFabrication Facility (BFF). The BFF printed the meniscus using living human cells and transmitted it to Redwire’s Advanced Space Experiment Processor for a 14-day enculturation process for BFF-Meniscus-2.
SpaceX’s Crew-6 mission returned the tissue to Earth after culturing. UAE astronaut Sultan Al-Neyadi and NASA astronauts Frank Rubio, Warren Hoburg, and Stephen Bowen investigated.
Redwire collaborated with the Uniformed Services University of the Health Sciences Center for Biotechnology, which studies warfighter remedies, for the trial. Meniscus injuries are the most prevalent orthopedic injuries in U.S. service members.
In recent months, Redwire Space has advanced biotechnology. The subsidiary of Redwire Corporation launched a 30,000-square-foot biotech and microgravity research park in Indiana this summer.
Redwire EVP John Vellinger called the printing “groundbreaking milestone.”
He stated, “Demonstrating the ability to print complex tissue such as this meniscus is a major leap forward toward the development of a repeatable microgravity manufacturing process for reliable bioprinting at scale.”
The company has long-term bioprinting and space microgravity research goals. Redwire will fly microgravity pharmaceutical drug development and cardiac tissue bioprinting payloads on a November SpaceX Commercial Resupply trip to the ISS.
Sierra Space agreed to integrate Redwire’s biotech and in-space manufacturing technology into its Large Integrated Flexible Environment (LIFE) space station module. Orbital Reef, a private space station designed by Blue Origin, Boeing, and others, will include LIFE.
Biology
The First 3D-Printed Vegan Salmon Is In Stores

Revo Foods’ “THE FILET – Inspired By Salmon” salmon fillet may be the first 3D-printed food to hit store shelves. said that firm CEO Robin Simsa remarked, “With the milestone of industrial-scale 3D food printing, we are entering a creative food revolution, an era where food is being crafted exactly according to customer needs.”
Mycoprotein from filamentous fungi is used to make the salmon alternative and other meat substitutes. Vitamins and omega-3 fatty acids are in the product, like in animals. Is high in protein, at 9.5 grams per 100 grams, although less than conventional salmon.
Revo Foods and Mycorena developed 3D-printable mycoprotein. Years of research have led to laser-cooked cheesecakes and stacked lab-grown meats.
One reason for this push is because printed food alternatives may make food production more sustainable, which worries the fishing sector. Overfishing reduces fish populations in 34% of worldwide fish stocks.
Over 25% of worldwide greenhouse gas emissions come from food production, with 31% from livestock and fish farms and 18% from supply chain components including processing and shipping. According to Revo Foods’ website, vegan salmon fillet production consumes 77 to 86% less carbon dioxide and 95% less freshwater than conventional salmon harvesting and processing.
The salmon alternative’s sales potential is unknown. In order to succeed, Revo Foods believes that such goods must “recreate an authentic taste that appeals to the flexitarian market.”
The commercial distribution of 3D-printed food could change food production.
Artificial Intelligence
Open-source Microsoft Novel protein-generating AI EvoDiff

All diseases are based on proteins, natural molecules that perform vital cellular functions. Characterizing proteins can reveal disease mechanisms and ways to slow or reverse them, while creating proteins can lead to new drug classes.
The lab’s protein design process is computationally and human resource-intensive. It involves creating a protein structure that could perform a specific function in the body and then finding a protein sequence that could “fold” into that structure. To function, proteins must fold correctly into three-dimensional shapes.
Not everything has to be complicated.
Microsoft introduced EvoDiff, a general-purpose framework that generates “high-fidelity,” “diverse” proteins from protein sequences, this week. Unlike other protein-generating frameworks, EvoDiff doesn’t need target protein structure, eliminating the most laborious step.
Microsoft senior researcher Kevin Yang says EvoDiff, which is open source, could be used to create enzymes for new therapeutics, drug delivery, and industrial chemical reactions.
Yang, one of EvoDiff’s co-creators, told n an email interview that the platform will advance protein engineering beyond structure-function to sequence-first design. EvoDiff shows that ‘protein sequence is all you need’ to controllably design new proteins.
A 640-million-parameter model trained on data from all protein species and functional classes underpins EvoDiff. “Parameters” are the parts of an AI model learned from training data that define its skill at a problem, in this case protein generation. The model was trained using OpenFold sequence alignment data and UniRef50, a subset of UniProt, the UniProt consortium’s protein sequence and functional information database.
Modern image-generating models like Stable Diffusion and DALL-E 2 are diffusion models like EvoDiff. EvoDiff slowly subtracts noise from a protein made almost entirely of noise to move it closer to a protein sequence.
Beyond image generation, diffusion models are being used to design novel proteins like EvoDiff, create music, and synthesize speech.
“If there’s one thing to take away [from EvoDiff], I think it’s this idea that we can — and should — do protein generation over sequence because of the generality, scale, and modularity we can achieve,” Microsoft senior researcher Ava Amini, another co-contributor, said via email. “Our diffusion framework lets us do that and control how we design these proteins to meet functional goals.”
EvoDiff can create new proteins and fill protein design “gaps,” as Amini noted. A protein amino acid sequence that meets criteria can be generated by the model from a part that binds to another protein.
EvoDiff can synthesize “disordered proteins” that don’t fold into a three-dimensional structure because it designs proteins in “sequence space” rather than structure. Disordered proteins enhance or decrease protein activity in biology and disease, like normal proteins.
EvoDiff research isn’t peer-reviewed yet. Microsoft data scientist Sarah Alamdari says the framework needs “a lot more scaling work” before it can be used commercially.
“This is just a 640-million-parameter model, and we may see improved generation quality if we scale up to billions,” Alamdari emailed. WeAI emonstrated some coarse-grained strategies, but to achieve even finer control, we would want to condition EvoDiff on text, chemical information, or other ways to specify the desired function.”
Next, the EvoDiff team will test the model’s lab-generated proteins for viability. Those who are will start work on the next framework.
Artificial Intelligence
CES 2023 :Learn the latest information from the greatest technology event of the year

Although the CES doesn’t start until tomorrow, we’re back in Vegas for the event, and several exhibitors have already shown their new items at numerous press conferences and media events. In addition to more news from TV manufacturers, gaming laptop manufacturers, smart home firms, and other companies, we are starting to see some of the early automotive news that typically headlines CES today. Here is a summary of the top news from Day 1 of CES 2023 in case you haven’t caught up yet.
Since last night
But first, even though we covered the most of yesterday’s launches in a different video, more things were announced last night after we had finished filming that. For instance, Withings demonstrated the $500 pee-scanning U-Scan toilet computer.
It’s a 90mm block that you install inside your toilet bowl as a deodorizer and employs a microfluidic device that functions like a litmus test to identify the components in your pee. Although Withings is developing a consumer-focused version that will evaluate your nutrition and hydration levels and forecast your ovulation and period cycles, you will need to decide the precise tests you wish to run in your module. Prior to launching in the US, it is still awaiting regulatory approval from the European Union.
We also witnessed the Fufuly pulsing cushion by Yukai Engineering, which was less… gross news. Although a vibrating cushion may sound like something out of an anime, the concept is that cuddling something that might simulate real-life pulsation may have calming effects. Another thing that could calm anxiety? watching a video of adorable birds! Additionally, Bird Buddy unveiled a brand-new intelligent feeder with a built-in camera so you can watch your feathered friends while they build nests. The most recent version, which is intended for hummingbirds, uses AI to recognize the different breeds that are in the area and, in conjunction with a motion sensor, determines when they are ready for a feast.
Speaking of nibbles, there was a ton of food-related technology news last night, like as the $1,000 stand mixer from GE Profile that has a digital scale and voice controls. We also observed OneThird’s freshness scanners, which determine the freshness of produce using near-infrared lasers and secret algorithms. Even the shelf life of an avocado can be determined instantly, preventing food waste!
We also witnessed the Wisear neural earbuds that let you control playback by clenching your jaw, the blood pressure monitor that hooks onto your finger from Valencell, and Loreal’s robotic lipstick applicator for people with limited hand or arm mobility. Smart speakers, smart pressure cookers, smart VR gloves, smart lights, and more were available.
Let’s move on to the recent news. Prior to the onslaught that is set to happen tomorrow, there was only a little trickle of auto news. Volkswagen debuted the ID.7 EV sedan, tempting us with only the name and a rough body form. BMW, meanwhile, revealed the I Vision Dee, or “Digital Emotional Experience,” to provide additional information about its futuristic I Vision concept vehicle development. It’s a simplified design with a heads-up display that spans the entire front windshield. Many of the Dee’s characteristics are anticipated to be incorporated into production vehicles starting in 2025, notably BMW’s new NEUE KLASSE (new class) EV platform. BMW’s Mixed Reality slider will also be available on the Dee to regulate how much digital stuff is shown on the display.
TVs
The premium 2023 TVs from Samsung were also not unveiled until the evening, with this year’s models emphasizing on MiniLED and 8K technologies. Additionally, it added more sizes to its selection and unveiled new soundbars with Dolby Atmos capability at all price points. While this was going on, competitor LG unveiled a 97-inch M3 TV that can wirelessly receive 4K 120Hz content, allowing you to deal with fewer connections in your living room and… more soundbars. Leave it to LG and Samsung to essentially duplicate each other’s actions.
Hisense, a competitor with comparatively smaller TVs, today announced its 85-inch UX Mini LED TV, which has more than 5,000 local dimming zones and a maximum brightness of 2,500 nits. Startup Displace, meanwhile, demonstrated a brand-new 55-inch wireless OLED TV that can be attached to any surface via vacuum suction, doing away entirely with the requirement for a wall mount or stand. You can even live without a power cord thanks to its four inbuilt batteries. Essentially, this is a fully functional, portable TV.
Laptops
We also noticed more HP, MSI, and ASUS laptops. A laptop with glasses-free 3D, a sizable Zenbook Pro 16X with lots of space for thermal dissipation, and a Zenbook 14X with a ceramic build are all products of ASUS. Both of the latter Zenbooks include OLED displays. In the meantime, HP unveiled a new line of Dragonfly Pro laptops that are designed to simplify the purchasing process for customers by removing the majority of configuration options. The Windows version exclusively uses an AMD CPU and has a column of hotkeys on the right of the keyboard that provide shortcuts to camera settings, a control center, and 24/7 tech support, whilst the Dragonfly Pro Chromebook has an RGB keyboard and Android-like Material You theming capabilities. The last of these buttons can be programmed to open a particular program, file, or website.
The first of some audio news is now being presented to us, starting with JBL. The business presented its array of five soundbar models for 2023, all of which will support Dolby Atmos. New true wireless earbuds with a “smart” casing including a 1.45-inch touchscreen and controls for volume, playback, ANC, and EQ presets were also introduced. Nearly simultaneously, HP unveiled the Poly Voyager earphones, which are comparable to the JBL in terms of controls and have a touchscreen on the carrying case. However, the Voyager also features a Broadcast mode that enables you to connect the case to an older device with a headphone port (like while you’re on an airline) via the provided 3.5mm to USB-C connection, so you can view movies during a flight without having to bring along a second set of headphones.
Not only today but also the remainder of the week will see a ton more CES news. I was unable to tell you about Citizen’s latest wristwatch or Samsung’s new, more affordable Galaxy A14 smartphone. Keep checking back for updates on all CES 2023 news.
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