Loneliness linked with changes at a cellular level that increase health risks
Not that we didn’t know, but humans are not capable of dealing with loneliness, we are social beings and we need the company of each other. A study performed by researchers, including psychologist and loneliness expert John Cacioppo from University of Chicago, proved that loneliness triggers some psychological, but also biological responses that lead to sickness.
A previous study made by this team found a link between loneliness and an abnormal response of genes, which showed increased expression in inflammation, but decreased expression in antiviral responses. The past study and the one made recently, involved both human and primates as test subjects and found that subjects that felt a deep feeling of loneliness were ultimately more susceptible to inflammation, while their immune systems were less responsive.
Their new study focused on a fight-or-flight stress signal produced by the feeling of loneliness which can increase or decrease the production on white blood cells. They’ve found the same effect as in their previous study, that loneliness causes an increased gene expression for inflammation while the gene expression for the immunes system’s fight against antiviral infections is decreased. But they have also found that the link between loneliness and gene expression is reciprocal. Loneliness can predict this effect, but also people who showed this modification of gene expression without feeling lonely, had a tendency of feeling loneliness in the months that followed.
Now, they are trying to find out if there is a way of changing this effects with some particular drugs, but only the link between loneliness and a poorly controlled immune response was proven. All in all, these modifications of immune and inflammatory response, lead to diseases or hard to treat sicknesses increases the chances of premature death by 14% in adults who experience loneliness on a daily basis.
Chinese Dinosaur Might Have Been as Iridescent as a Hummingbird
Earlier this month, I wrote an article on a toy line of scientifically accurate Velociraptor action figures with plumage inspired by modern birds. I mused how impressive it would be if prehistoric raptors had been covered by feather patterns not unlike those in the toy line. Little did I know that two weeks later, researchers would reveal that some theropods had iridescent feathers that outshine David Silva’s velocifigures.
The Caihong juji, Mandarin for “rainbow with a big crest” (or just Caihong for short), was a “paravian theropod,” a clade commonly known for its winged forelimbs (even though many weren’t capable of flight) and enlarged sickle foot claws. In 2014, a farmer in the Qinlong County in the Hebei Province of Northeastern China gave a nearly complete Caihong fossil, feathers included, to The Paleontological Museum of Liaoning. Finding a complete skeleton is rare in paleontology and proved very helpful to the researchers. However, you might wonder just how scientists were able to determine the iridescent nature of the Caihong’s plumage. Two words: fossilized melanosomes.
Melanosomes are organelles that create, store, and transport melanin, which determines the pigments/colors of animal hair, fur, skin, scales, and feathers. Upon examining the Caihong’s head, crest, and tail feathers with an electron microscope, scientists discovered platelet-shaped structures similar in shape to the melanosomes that give hummingbirds their iridescent coloring. The rest of the body feathers had melanosome structures similar to those in the grey and black feathers of penguins, which would have made for an odd sight: a duck-sized dinosaur with body feathers as drab as a raven’s and head and neck feathers more colorful than a peacock’s.
The inferred feather coloration of the Caihong is not its only unusual feature, though. The dinosaur had longer arm and leg feathers than its relatives, and its tail feathers created a “tail surface area” that was larger than the famous proto-bird the Archaeopteryx. Furthermore, the Caihong had bony crests, which while common among most dinosaurs, are almost unheard of among paravian theropods. But, more importantly, it had proportionally long forearms, which is a feature of flight-capable theropods, even though scientists believe the Caihong didn’t fly. While this dinosaur apparently has the earliest examples of proportionally long forearms in the theropod fossil records, it still falls in line with the belief that the evolution of flight-capable feathers outpaced the evolution of flight-capable skeletons. The melanosomes, however, are the more intriguing discovery, since they are the earliest examples of “organized platlet-shaped nanostructures…in dinosaurian feathers.”
While paleontologists are confident the Caihong’s platelet structures are melanosomes, the researchers understand that their discovery is based partially on inference and could potentially be incorrect. If the structures aren’t melanosomes, well, that invalidates this entire article. But that’s what paleontology is all about: examining the evidence, creating inferences supported by that evidence, and changing those inferences when new information becomes available. Still, the concept of dinosaurs with iridescent feathers is pretty cool. If you want to learn more about the Caihong juji, you can read the original article on Nature.
Scientists Discover Velociraptor’s Cousin, and It Looks Like a Swan
When we hear the word Velociraptor, we usually think about the clever girls from Jurassic Park/World. In my case, I think about Dinobot from Beast Wars, but that’s neither here nor there, because after you’re done reading this article, you won’t be able to get the following thought out of your head: Velociraptors are related to a dinosaur best described as a prehistoric swan. Good luck ever seeing ol’ sickle claw the same way again.
Say hello to the Halszkaraptor essuilliei (Halszka for short), a dinosaur recently discovered at Ukhaa Tolgod (part of the Djadochta Formation in the Gobi Desert in Mongolia) by a team of paleontologists led by Andreau Cau of the Geological Museum Capellini in Bologna, Italy. Halszka’s around 75 million years old, which means he was alive during the late Cretaceous period during what is known as the Campanian age. And if you’re wondering why he looks like a swan, that’s because, according to a 3D synchrotron analysis (a process that uses x-rays so powerful they can only be produced in facilities the size of football stadiums), he’s semi-aquatic. Doesn’t he just look adorable?
Halszka belongs to the suborder therapod, known for specimens such as Tyrannosaurus Rex, the Velociraptor, and the ostrich. Therapods are known for their efficacy on land, but until the Halszkaraptor’s discovery, scientists thought they were exclusive to solid ground. Sure, some therapods might have eaten fish from time to time, but Halszka is the only known therapod with aquatic tendencies.
“The first time I examined the specimen, I even questioned whether it was a genuine fossil,” explained Cau. “This unexpected mix of traits makes it difficult to place Halszka within traditional classifications.” Given the long, swan-like neck, dinky flippers, and sickle-shaped claws reminiscent of the Velociraptor, I can’t blame him for being confused. Zoologists went through the same problem when they examined the first known platypus back in 1799; who wouldn’t be confused by such disparate features? “When we look beyond fossil dinosaurs, we find most of Halszkaraptor‘s unusual features among aquatic reptiles and swimming birds,” Cau continued. “The peculiar morphology of Halszkaraptor fits best with that of an amphibious predator that was adapted to a combined terrestrial and aquatic ecology: a peculiar lifestyle that was previously unreported in these dinosaurs. Thanks to synchrotron tomography, we now demonstrate that raptorial dinosaurs not only ran and flew, but also swam!”
Halszka now proudly sits as the first of a new genus of amphibious dinosaurs, capable of using its legs to walk on land and swim through the water and with a posture likely similar to those of modern day ducks and swans. Since the Gobi Desert, especially the Djadoctha Formation, appears to be a hotbed of important paleontological finds, many of which are therapods related to Halszka, who knows how many other amphibious dinosaurs are waiting to be discovered? Halszka could either be one of many previously undiscovered swimming raptors or as unique as the Mesonychid; nature’s first and only attempt at a hoofed predator.
If you are interested in reading Cau’s paper on the Halszkaraptor essuilliei, you can read the article on Nature. However, if you do not have a subscription, you should either read the Science Daily article or Andreau Cau’s personal blog (it is in Italian but an English translation is readily available on the page).
Researchers Use Stem Cells to Help Rats with Paraplegia Walk Again
Spinal cord injuries (SCIs) harm the nerves housed in the spinal cord, often causing irreversible damage to the body and its functions. Normally, physicians and other clinicians can only help people adapt to their SCIs instead of healing them, but researchers at Tel Aviv University and the Technion-Israel Institute of Technology might have discovered an essential key in the search for a possible cure. Just a word of warning: this article contains descriptions of animal experimentation, so some information might not be suitable for some readers.
Dr. Shulamit Levenberg of the Technion-Israel Institute of Technology recently led a multi-university study to determine if lab rats with simulated complete spinal cord injuries could regain the use of their hind legs with the introduction of stem cells and tissue engineered scaffolds. Some stem cells had been induced to differentiate (i.e., develop into different type of cells such as support cells), while others hadn’t been induced at all. And, the scaffolds were designed to “provide a 3D environment in which cells can attach, grow and differentiate, maintain cell distribution, and provide graft protection following transplantation.” In other words, the scaffolds made sure the stem cells grew as intended and weren’t accidentally damaged.
Researchers took lab rats and surgically removed a small portion of the lamina (the bony plates of the vertebrae that protect the spinal column and the vulnerable nerves) and cut through all of the nerves. Since incomplete spinal cord injuries only damage some nerves and can, for example, leave people unable to move their legs but capable of feeling through them or vice versa, the researchers had to sever all the nerves to simulate a complete spinal cord injury. Some rats were then implanted with the scaffold and stem cells (some of which were induced and some of which were not) to bridge the severed nerves. Other rats were implanted only with the scaffold, and a control group received neither scaffold nor stem cells.
After the scaffolds and stem cells were implanted, the researchers stitched up all the rats, including the control group, and observed them for any improvements. Rats that received both the scaffold and induced stem cells recovered better than the other groups; 42% of these rats were able to walk and support their body weight with their hind legs after three weeks. Furthermore 75% of this group reacted to stimuli in their hind legs and tail. Fewer rats with the non-induced stem cells recovered as fully as the rats with the induced stem cells. Furthermore, researchers found the scaffold-only group could not respond to any stimuli in their hind legs or tail, and rats in the control group did not improve at all.
While the study demonstrates that induced stem cells coupled with tissue engineered scaffolds could potentially help people with SCIs walk again, the number of rats who fully recovered was fairly low. Still, the results are promising and lay the groundwork for future studies that might one day develop a cure for SCIs. The full article on Levenberg’s study can be found on Frontiers.
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