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Clinical trials are currently underway in the United States to test the efficacy of HIV PrEP injections that only need to be administered every 6 months

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Trials for a novel variant of extended-release pre-exposure prophylaxis (PrEP), a preventive treatment for HIV, have commenced in the United States. In addition to potentially providing a new approach for HIV prevention, the trials are specifically targeting two marginalized populations that have historically been neglected in HIV research: cisgender women and individuals who engage in injectable drug use.

The implementation of PrEP marked a significant advancement in the ongoing battle against HIV. When used in accordance with medical instructions, it decreases the likelihood of acquiring HIV through sexual intercourse by 99 percent and through intravenous drug use by 74 percent.

PrEP typically consists of a daily pill regimen to ensure optimal protection. In 2021, the Food and Drug Administration (FDA) granted approval for an injectable version of PrEP that is administered every two months. However, this form of PrEP is not yet widely accessible.

The ongoing clinical trials are testing a novel form of PrEP designed to be administered every six months, aiming to enhance convenience and accessibility for certain individuals. The treatment utilizes lenacapavir, an FDA-approved drug specifically designed for managing HIV that is resistant to conventional therapies.

The University of California San Diego Antiviral Research Center is currently running trials that are actively recruiting people from two groups that have not been adequately represented in HIV research in the past: cisgender women (people whose biological sex is female and whose gender identity corresponds to this), with a focus on black and Latina participants; and people who currently inject drugs, such as opioids and cocaine.

According to a statement from the National Institutes of Health (NIH), these populations represent 18 percent and 7 percent of new HIV diagnoses in the US, respectively. According to HIV.gov, 70 percent of newly acquired HIV infections in 2021 were among men who engaged in sexual activity with other men. However, there has been an increase in demand in recent years for trials and investigations to include a wider range of people affected by this virus.

The studies will be conducted at various locations throughout the United States, enrolling individuals who meet the specified criteria for inclusion and who could potentially derive advantages from using PrEP. Participants will be assigned at random to receive either the new lenacapavir injections or an oral PrEP formulation that has already been approved for use. The researchers will prioritize the examination of safety, the mechanism of action of the drug within the body, and the assessment of potential side effects experienced by the participants.

The prognosis for individuals recently diagnosed with HIV has significantly improved over the past five decades. The promotion of safe sexual practices has significantly contributed to preventing infection in numerous individuals. Furthermore, advancements in antiretroviral treatments have made it feasible for many individuals to achieve an undetectable viral load, thereby eliminating the risk of transmitting the infection. The recent implementation of PrEP provided individuals at risk with an additional means of safeguarding themselves against infection.

It will take a considerable amount of time before we observe any outcomes from these trials. However, if they prove to be successful, it could introduce a more easily attainable method of preventing HIV infection. Additionally, it would enhance our scientific understanding of marginalized groups, who are frequently overlooked in discussions.

As Editor here at GeekReply, I'm a big fan of all things Geeky. Most of my contributions to the site are technology related, but I'm also a big fan of video games. My genres of choice include RPGs, MMOs, Grand Strategy, and Simulation. If I'm not chasing after the latest gear on my MMO of choice, I'm here at GeekReply reporting on the latest in Geek culture.

Medicine and Health

Microplastics have been detected in the male genitalia of humans for the first time

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Researchers have recently discovered microplastics in human penises, expanding the list of body parts where these harmful particles have been detected.

Microplastics are small pieces of plastic that are shorter than 5 millimeters (0.2 inches) and can originate from various sources, including plastic production or the breakdown of plastic objects. With their apparent penetration into every small space, some people are worried about the potential consequences for our well-being.

The initial phase of this process involves determining their presence within the body. Researchers from the University of Miami, the University of Colorado, and the research institution Helmholtz-Zentrum Hereon embarked on a quest to ascertain whether these entities could be detected in penises.

In order to accomplish this, the team collected penile tissue samples from six individuals who were undergoing surgery to treat erectile dysfunction. One of the samples was used as a control for comparison. Subsequently, the samples were examined for microplastics using laser direct infrared (LDIR) microspectroscopy, a method that enables scientists to identify the types, sizes, and quantities of microplastics present.

The analysis indicated that microplastics were present in 80 percent of the samples, with sizes ranging from 20 to 500 micrometers. However, another microscopy technique detected some microplastics as small as 2 micrometers (equivalent to thousandths of a millimeter, for reference to their minuscule size).

The microplastics (MPs) consisted of seven distinct types, with polyethylene terephthalate being the most abundant at 47.8 percent. Polyethylene terephthalate (PET), a type of plastic, is frequently utilized in the manufacturing of clothing as well as packaging for food and beverages.

Polypropylene, accounting for 34.7 percent of the sample, emerged as the second most prevalent plastic. This versatile plastic is utilized in various applications, including rigid food packaging and plastic laboratory equipment.

The authors state that their study is a pioneering investigation into the existence of microplastics (MPs) in penile tissue. “Our research provides important information about the presence of MPs in human tissues, which contributes significantly to the ongoing discussion about the impact of environmental pollutants on human health.”

While this study represents the initial discovery of microplastics in penile tissue, previous findings have already identified their presence in the surrounding region. In a recent study, scientists discovered substantial amounts of microplastics in the testes of both humans and dogs. Additionally, another investigation revealed the presence of microplastics in all 36 semen samples examined by the researchers.

Scientists have consistently highlighted the need for further research, but they have indicated the potential impact of microplastics on reproductive health, specifically investigating the connection between microplastics and erectile dysfunction.

In an interview with Sky News, Dr. Ranjith Ramasamy, the main researcher, stated that further investigation is needed to understand the mechanism behind the presence of microplastics in the penis.

The research is published in the International Journal of Impotence Research

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Medicine and Health

Long-Term COVID Risk Factors Found in Data from Almost 5,000 People

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More information about who may be most likely to get a long-lasting illness has been found by looking at data from 4,700 people who have recovered from COVID-19. Scientists still don’t know exactly what causes the painful symptoms of long COVID—there are hundreds of possible causes—but this new study gives them a better idea of who may be affected.

If you get infected with SARS-CoV-2, you will have a long-term condition called Long COVID for at least three months. The symptoms may get worse over time or come on and off in waves. Some people will get better after a while, but for others, whose symptoms started in the early days of the pandemic in 2020 and haven’t gone away yet, they are still sick.

A lot of work has been done by scientists to figure out what causes long-term COVID and to find treatments that might help, not just for these patients but also for people with other post-viral syndromes. There are still a lot of things we don’t know, though. One of the biggest questions is who may be most likely to get long-term COVID. Someone at the Columbia University Irving Medical Center may have led a new study that could help.

“Our study clearly establishes that COVID posed a substantial personal and societal burden,” said Professor Elizabeth C. Oelsner, who wrote the study and was the lead author. “By figuring out who was most likely to have had a long recovery, we have a better idea of who should be involved in ongoing research into how to lessen or stop the long-term effects of SARS-CoV-2 infection.”

The 4,700 people who took part in the study agreed to be a part of the Collaborative Cohort of Cohorts for COVID-19 Research, or C4R. C4R is made up of more than 50,000 people from all over the US who are doing long-term research to help us learn as much as we can about the COVID-19 pandemic.

The people who took part were asked to say how long it took them to get better after getting COVID. The average time to get better from an infection between 2020 and 2023 was 20 days, and more than one in five adults had symptoms for at least three months.

The biggest groups of those were found to be women and people who already had heart disease. American Indian and Alaska Native people who took part also had more severe first infections and took longer to recover.

Being vaccinated against the virus and having an infection with an omicron lineage variant, which is usually linked to milder disease, were both linked to a faster recovery. She said, “Our study shows how important it is that COVID vaccinations have been, not only in lowering the severity of an infection but also in lowering the risk of long-term COVID.”

Other health problems that are usually linked to worse outcomes from COVID, like diabetes and chronic lung disease, were linked to longer recovery times. However, this was no longer a statistically significant finding when sex, heart disease, vaccination status, and variant exposure were taken into account.

The study also found an interesting lack of a significant link with mental health disorders. Studies have shown that a lot of people with long COVID have problems with their mental health, but Oelsner said, “We did not find that depressive symptoms before SARS-CoV-2 infection were a major risk factor for long COVID.”

The main thing to remember is that getting vaccinated is still the best way to avoid getting COVID in the first place, so make sure you don’t have a worse experience with it. The current circulating variants are mostly offshoots of Omicron. This may also be a reason to be hopeful, since these variants were linked to shorter recovery times.

New vaccines are being made to match the newest strains, and the Centers for Disease Control and Prevention (CDC) puts out detailed information on when people of different ages and risk levels should think about getting their next booster. Different countries have different vaccine availability, but the health authority in your area should be able to tell you if you can get a shot.

The study can be found in JAMA Network Open.

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Medicine and Health

Which is better for us: fresh or frozen vegetables?

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People are changing how they shop at the grocery store to save money because the cost of living is going up. This is especially true when it comes to vegetables. As a general rule, frozen vegetables are less expensive than fresh ones. However, some people think that fresh vegetables are naturally “better” for you. Which is it?

In a clean corner
Fresh vegetables that are crunchy and taste great are great, but they might not have as many nutrients as you think.

They start to lose their nutrients as soon as they are picked. That’s because they are taken away from their source of nutrients when they are picked. So that they can stay alive, the cells in vegetables breathe faster, which can cause nutrients to be lost. It’s also possible for this to happen when vegetables are stored or processed and are exposed to oxygen.

But this is the big nutritional catch with fresh vegetables: how healthy they are depends on how soon you eat them after picking them. Since the prices of vegetables at stores are going through the roof, some people are growing their own or getting them from community gardens. It usually takes a little longer for fresh vegetables from the store to get to our tables.

To get the most out of fresh vegetables, they should be eaten within a few days, if possible. CNN Health spoke with Gene Lester, a plant physiologist and national program leader for the US Department of Agriculture. “After it’s four, five, or seven days old, it’s a whole different story.”

In the cold corner
It became popular to freeze fresh vegetables because they go bad faster when left out in the open air. This way, you can use them up faster and avoid having a fridge full of spoiled green beans. Besides that, because they are frozen so soon after being picked, frozen vegetables are usually thought to have more nutrients.

Still, there is some evidence that frozen vegetables may have less vitamin C than fresh vegetables. Vitamin C is important for many bodily functions and, you know, keeps you from getting scurvy. For that reason, frozen vegetables are blanched, which means they are quickly scalded in steam or boiling water and then quickly cooled.

Blanching food is thought to help keep the flavor and stop that weird gray color that can happen with frozen food. This is done by turning off enzymes in the vegetables, which freezing alone couldn’t do. But heat can also break down vitamin C, so some of it might be lost in vegetables that are going to be frozen.

Vitamin C loss doesn’t seem to be that clear-cut, though. If it’s frozen, there may not be any more loss.

A study from 2015 that looked at how well eight different fruits and vegetables kept their vitamins found that spinach, carrots, peas, and broccoli that were stored fresh or frozen did not differ significantly in terms of vitamin C. It was discovered that frozen corn and green beans had higher levels of vitamin C than fresh ones. The authors said this was because fresh vegetables break down faster.

The whole picture
The study mentioned above also discovered that, on average, frozen vegetables had the same amount of vitamins as fresh ones, and sometimes even more. Any food is “better” than none at all, and any vegetable is better than none at all in the big picture.

Vegetables are full of fiber, vitamins, and minerals, and they are good for you in many ways, like helping your immune system and giving you more energy.

If you can’t decide between fresh and frozen, choose the option that works best for you, whether it’s financially, practically, or just in terms of taste.

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